Enables adenine transmembrane transporter activity; guanine transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in hypoxanthine transport. Located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC43A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC43A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC43A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,212,992–57,214,202 | 213.6 kb | Distal (>10kb) Multiome | 248 | |
| chr11:57,236,823–57,238,006 | 189.6 kb | Distal (>10kb) Multiome | 256 | |
| chr11:57,242,064–57,242,828 | 184.6 kb | Distal (>10kb) Multiome | 232 | |
| chr11:57,277,829–57,278,561 | 149.0 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,310,924–57,312,111 | 115.6 kb | Distal (>10kb) Multiome | 620 | |
| chr11:57,323,847–57,325,914 | 102.1 kb | Distal (>10kb) Multiome | 790 | |
| chr11:57,335,065–57,336,267 | 91.3 kb | Distal (>10kb) Multiome | 689 | |
| chr11:57,345,508–57,346,149 | 81.3 kb | Distal (>10kb) Multiome | 241 | |
| chr11:57,349,624–57,350,269 | 77.1 kb | Distal (>10kb) Multiome | 357 | |
| chr11:57,424,742–57,425,205 | 1.9 kb | Proximal (<10kb) | 487 | |
| chr11:57,426,113–57,427,448 | 21 bp | At TSS Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 30.4 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 33.5 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,480,236–57,481,014 | 53.4 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 56.0 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 66.6 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 72.7 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 87.4 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 103.8 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 141.0 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 171.0 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 211.1 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 217.9 kb | Distal (>10kb) Multiome | 237 | |
| chr11:57,646,682–57,652,802 | 222.8 kb | Distal (>10kb) Multiome | 580 | |
| chr11:57,656,843–57,658,231 | 230.5 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 240.7 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 285.2 kb | Distal (>10kb) Multiome | 857 |
Genomic view of the SLC43A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.