SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC43A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC43A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC43A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,277,829–57,278,561 | 237.6 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,310,924–57,312,111 | 204.2 kb | Distal (>10kb) Multiome | 620 | |
| chr11:57,323,847–57,325,914 | 190.7 kb | Distal (>10kb) Multiome | 790 | |
| chr11:57,335,065–57,336,267 | 179.9 kb | Distal (>10kb) Multiome | 689 | |
| chr11:57,345,508–57,346,149 | 169.9 kb | Distal (>10kb) Multiome | 241 | |
| chr11:57,349,624–57,350,269 | 165.8 kb | Distal (>10kb) Multiome | 357 | |
| chr11:57,426,113–57,427,448 | 88.6 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 58.3 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 54.3 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,482,336–57,483,518 | 32.6 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 22.0 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 15.9 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 1.2 kb | Proximal (<10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 15.2 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 52.4 kb | Distal (>10kb) Multiome | 665 | |
| chr11:57,597,419–57,598,821 | 82.4 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 123.8 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,644,541–57,645,304 | 129.2 kb | Distal (>10kb) Multiome | 237 | |
| chr11:57,656,843–57,658,231 | 141.9 kb | Distal (>10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 152.1 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 196.5 kb | Distal (>10kb) Multiome | 857 | |
| chr11:57,740,872–57,742,140 | 225.7 kb | Distal (>10kb) Multiome | 973 | |
| chr11:57,761,276–57,762,144 | 246.1 kb | Distal (>10kb) Multiome | 612 | |
| chr11:57,778,066–57,779,000 | 263.0 kb | Distal (>10kb) Multiome | 688 | |
| chr11:57,780,962–57,781,951 | 266.0 kb | Distal (>10kb) Multiome | 317 |
Genomic view of the SLC43A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.