Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC39A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC39A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC39A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:35,849,802–35,850,882 | 279.2 kb | Distal (>10kb) Multiome | 177 | |
| chr18:35,851,060–35,852,119 | 277.8 kb | Distal (>10kb) Multiome | 244 | |
| chr18:35,949,718–35,950,700 | 179.1 kb | Distal (>10kb) Multiome | 420 | |
| chr18:35,971,798–35,973,006 | 156.9 kb | Distal (>10kb) Multiome | 1056 | |
| chr18:36,066,875–36,067,975 | 61.8 kb | Distal (>10kb) Multiome | 832 | |
| chr18:36,128,266–36,130,354 | 188 bp | At TSS Multiome | 1064 | |
| chr18:36,186,392–36,188,500 | 58.1 kb | Distal (>10kb) Multiome | 747 | |
| chr18:36,296,503–36,298,742 | 168.3 kb | Distal (>10kb) Multiome | 532 |
Genomic view of the SLC39A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.