Predicted to enable L-glutamate transmembrane transporter activity and L-glutamine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and glutamine transport. Predicted to be located in membrane and synapse. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLC38A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC38A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC38A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:60,648,454–60,651,189 | 330.3 kb | Distal (>10kb) Multiome HiCAR | 790 | |
| chr14:60,655,802–60,657,953 | 323.9 kb | Distal (>10kb) Multiome HiCAR | 631 | |
| chr14:60,720,299–60,724,768 | 256.8 kb | Distal (>10kb) Multiome HiCAR | 933 | |
| chr14:60,980,625–60,981,938 | 10 bp | At TSS Multiome | 866 | |
| chr14:61,254,867–61,255,650 | 274.0 kb | Distal (>10kb) Multiome HiCAR | 219 | |
| chr14:61,280,136–61,281,846 | 300.2 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the SLC38A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.