The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for SLC38A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC38A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC38A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,475,845–48,476,469 | 7.5 kb | Proximal (<10kb) | 613 | |
| chrX:48,508,766–48,509,247 | 40.6 kb | Distal (>10kb) Multiome | 400 | |
| chrX:48,521,369–48,522,158 | 53.4 kb | Distal (>10kb) Multiome | 519 | |
| chrX:48,539,185–48,540,294 | 71.3 kb | Distal (>10kb) Multiome | 658 | |
| chrX:48,574,090–48,575,023 | 106.2 kb | Distal (>10kb) Multiome | 779 | |
| chrX:48,597,350–48,598,476 | 129.6 kb | Distal (>10kb) Multiome | 660 | |
| chrX:48,676,132–48,677,132 | 208.2 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 228.4 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 269.1 kb | Distal (>10kb) Multiome | 580 |
Genomic view of the SLC38A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.