This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for SLC36A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC36A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC36A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:151,080,524–151,081,640 | 266.6 kb | Distal (>10kb) Multiome | 916 | |
| chr5:151,157,085–151,158,664 | 189.8 kb | Distal (>10kb) Multiome | 760 | |
| chr5:151,223,077–151,224,282 | 123.6 kb | Distal (>10kb) Multiome | 662 | |
| chr5:151,252,199–151,253,942 | 94.6 kb | Distal (>10kb) Multiome | 746 | |
| chr5:151,348,447–151,349,638 | 1.4 kb | Proximal (<10kb) Multiome | 138 | |
| chr5:151,405,271–151,406,618 | 58.0 kb | Distal (>10kb) Multiome | 175 | |
| chr5:151,447,360–151,448,441 | 100.0 kb | Distal (>10kb) Multiome | 900 | |
| chr5:151,496,053–151,496,694 | 148.7 kb | Distal (>10kb) Multiome | 64 | |
| chr5:151,500,606–151,501,090 | 153.3 kb | Distal (>10kb) Multiome HiCAR | 332 |
Genomic view of the SLC36A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.