Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC35B2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC35B2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC35B2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:44,002,061–44,003,708 | 254.8 kb | Distal (>10kb) Multiome | 581 | |
| chr6:44,126,767–44,128,943 | 130.0 kb | Distal (>10kb) Multiome | 845 | |
| chr6:44,151,741–44,152,312 | 105.5 kb | Distal (>10kb) Multiome | 575 | |
| chr6:44,185,920–44,186,571 | 71.3 kb | Distal (>10kb) Multiome | 95 | |
| chr6:44,202,490–44,203,242 | 54.7 kb | Distal (>10kb) Multiome | 229 | |
| chr6:44,216,763–44,217,285 | 40.5 kb | Distal (>10kb) Multiome | 139 | |
| chr6:44,218,945–44,220,120 | 38.0 kb | Distal (>10kb) Multiome | 799 | |
| chr6:44,223,166–44,224,465 | 33.9 kb | Distal (>10kb) Multiome | 783 | |
| chr6:44,234,203–44,235,350 | 22.7 kb | Distal (>10kb) Multiome | 499 | |
| chr6:44,237,380–44,238,386 | 19.6 kb | Distal (>10kb) Multiome | 969 | |
| chr6:44,245,610–44,248,192 | 9.5 kb | Proximal (<10kb) Multiome | 1271 | |
| chr6:44,254,609–44,255,697 | 1.8 kb | Proximal (<10kb) | 430 | |
| chr6:44,256,209–44,258,064 | 106 bp | At TSS Multiome | 1042 | |
| chr6:44,264,892–44,265,788 | 8.0 kb | Proximal (<10kb) Multiome | 760 | |
| chr6:44,270,373–44,271,349 | 13.5 kb | Distal (>10kb) Multiome | 166 | |
| chr6:44,275,626–44,276,572 | 18.5 kb | Distal (>10kb) Multiome | 330 | |
| chr6:44,297,234–44,298,035 | 40.2 kb | Distal (>10kb) Multiome | 356 | |
| chr6:44,312,866–44,313,523 | 55.7 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:44,342,481–44,342,962 | 85.2 kb | Distal (>10kb) Multiome | 133 | |
| chr6:44,387,185–44,388,395 | 130.1 kb | Distal (>10kb) Multiome | 955 | |
| chr6:44,469,799–44,470,296 | 212.4 kb | Distal (>10kb) Multiome | 375 | |
| chr6:44,475,548–44,476,402 | 218.4 kb | Distal (>10kb) Multiome | 587 | |
| chr6:44,542,501–44,543,177 | 285.4 kb | Distal (>10kb) Multiome | 93 |
Genomic view of the SLC35B2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.