This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for SLC30A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC30A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC30A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:68,922,292–68,922,890 | 171.4 kb | Distal (>10kb) Multiome | 63 | |
| chr5:69,093,377–69,094,772 | 49 bp | At TSS Multiome | 952 | |
| chr5:69,166,575–69,167,819 | 73.0 kb | Distal (>10kb) Multiome | 840 | |
| chr5:69,188,979–69,190,115 | 95.6 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,217,542–69,218,587 | 124.0 kb | Distal (>10kb) Multiome | 898 | |
| chr5:69,234,302–69,235,305 | 140.8 kb | Distal (>10kb) Multiome | 732 | |
| chr5:69,300,544–69,301,286 | 206.9 kb | Distal (>10kb) Multiome | 217 | |
| chr5:69,368,998–69,370,235 | 275.7 kb | Distal (>10kb) Multiome | 956 |
Genomic view of the SLC30A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.