SLC30A1

SLC30A1

solute carrier family 30 member 1 | ZRC1, ZNT1

Predicted to enable calcium channel inhibitor activity and zinc:proton antiporter activity. Involved in defense response to bacterium; intracellular zinc ion homeostasis; and zinc ion import into organelle. Located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC5

Biological processes 76 terms

Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Schaffer collateral - CA1 synapse (GO:0098685)T-tubule (GO:0030315)T-tubule (GO:0030315)basolateral plasma membrane (GO:0016323)basolateral plasma membrane (GO:0016323)cadmium ion transmembrane transport (GO:0070574)cadmium ion transmembrane transport (GO:0070574)calcium channel inhibitor activity (GO:0019855)calcium channel inhibitor activity (GO:0019855)calcium channel inhibitor activity (GO:0019855)calcium ion import (GO:0070509)calcium ion transmembrane transport (GO:0070588)calcium:monoatomic cation antiporter activity (GO:0015368)calcium:monoatomic cation antiporter activity (GO:0015368)copper ion transport (GO:0006825)copper ion transport (GO:0006825)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic vesicle (GO:0031410)cytoplasmic vesicle membrane (GO:0030659)cytoplasmic vesicle membrane (GO:0030659)defense response to bacterium (GO:0042742)dendrite (GO:0030425)detoxification of cadmium ion (GO:0071585)detoxification of zinc ion (GO:0010312)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)glutamatergic postsynaptic density (GO:0099573)intracellular calcium ion homeostasis (GO:0006874)intracellular calcium ion homeostasis (GO:0006874)intracellular zinc ion homeostasis (GO:0006882)intracellular zinc ion homeostasis (GO:0006882)intracellular zinc ion homeostasis (GO:0006882)intracellular zinc ion homeostasis (GO:0006882)membrane (GO:0016020)membrane (GO:0016020)monoatomic cation transmembrane transporter activity (GO:0008324)monoatomic cation transport (GO:0006812)negative regulation of calcium ion import (GO:0090281)negative regulation of calcium ion import (GO:0090281)negative regulation of neurotransmitter secretion (GO:0046929)negative regulation of neurotransmitter secretion (GO:0046929)negative regulation of zinc ion transmembrane import (GO:0071584)negative regulation of zinc ion transmembrane import (GO:0071584)nuclear membrane (GO:0031965)nuclear membrane (GO:0031965)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of dendritic spine morphogenesis (GO:0061003)postsynaptic density membrane (GO:0098839)postsynaptic density, intracellular component (GO:0099092)protein binding (GO:0005515)regulation of postsynaptic density protein 95 clustering (GO:1902897)transmembrane transport (GO:0055085)zinc export across plasma membrane (GO:0140882)zinc export across plasma membrane (GO:0140882)zinc ion import into organelle (GO:0062111)zinc ion import into organelle (GO:0062111)zinc ion transmembrane transport (GO:0071577)zinc ion transmembrane transport (GO:0071577)zinc ion transmembrane transporter activity (GO:0005385)zinc ion transmembrane transporter activity (GO:0005385)zinc ion transmembrane transporter activity (GO:0005385)zinc ion transmembrane transporter activity (GO:0005385)zinc ion transport (GO:0006829)zinc ion transport (GO:0006829)zinc ion transport (GO:0006829)zinc:proton antiporter activity (GO:0140826)zinc:proton antiporter activity (GO:0140826)zinc:proton antiporter activity (GO:0140826)zinc:proton antiporter activity (GO:0140826)

Expression (TPM)

TFs regulating SLC30A1 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC30A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC30A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SLC30A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC30A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr1:211,326,284–211,327,905	252.3 kb	Distal (>10kb) Multiome	543
	chr1:211,375,133–211,375,818	203.7 kb	Distal (>10kb) Multiome	107
	chr1:211,382,531–211,383,307	196.4 kb	Distal (>10kb) Multiome	921
	chr1:211,398,188–211,399,458	180.4 kb	Distal (>10kb) Multiome	128
	chr1:211,399,597–211,400,219	179.0 kb	Distal (>10kb) Multiome	80
	chr1:211,416,272–211,417,162	162.5 kb	Distal (>10kb) Multiome	257
	chr1:211,469,768–211,470,490	109.0 kb	Distal (>10kb) Multiome	383
	chr1:211,513,158–211,514,512	65.0 kb	Distal (>10kb) Multiome	484
	chr1:211,515,159–211,516,023	63.5 kb	Distal (>10kb) Multiome	818
	chr1:211,577,546–211,580,066	219 bp	At TSS Multiome	1012
	chr1:211,630,152–211,630,733	51.2 kb	Distal (>10kb) Multiome	515
	chr1:211,655,045–211,655,900	76.2 kb	Distal (>10kb) Multiome	351
	chr1:211,667,030–211,667,875	88.3 kb	Distal (>10kb) Multiome	301
	chr1:211,675,193–211,676,330	96.6 kb	Distal (>10kb) Multiome	936
	chr1:211,695,364–211,695,890	116.5 kb	Distal (>10kb) Multiome	283
	chr1:211,698,066–211,699,596	119.5 kb	Distal (>10kb) Multiome	651
	chr1:211,829,926–211,831,171	251.6 kb	Distal (>10kb) Multiome	682

Genome Browser

Genomic view of the SLC30A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.