Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]
Transcription factors with Perturb-seq knockdown data for SLC2A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC2A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC2A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:133,238,117–133,239,420 | 240.5 kb | Distal (>10kb) Multiome | 620 | |
| chr9:133,335,737–133,336,702 | 142.9 kb | Distal (>10kb) Multiome | 1038 | |
| chr9:133,347,434–133,348,830 | 131.0 kb | Distal (>10kb) Multiome | 893 | |
| chr9:133,356,029–133,357,223 | 122.6 kb | Distal (>10kb) Multiome | 648 | |
| chr9:133,375,394–133,376,740 | 102.9 kb | Distal (>10kb) Multiome | 834 | |
| chr9:133,417,747–133,418,516 | 61.0 kb | Distal (>10kb) Multiome | 1015 | |
| chr9:133,428,444–133,429,113 | 50.4 kb | Distal (>10kb) Multiome | 255 | |
| chr9:133,429,621–133,430,196 | 49.2 kb | Distal (>10kb) Multiome | 197 | |
| chr9:133,458,883–133,460,984 | 19.3 kb | Distal (>10kb) Multiome | 835 | |
| chr9:133,478,485–133,479,696 | 66 bp | At TSS Multiome | 653 | |
| chr9:133,486,368–133,486,599 | 7.2 kb | Proximal (<10kb) | 361 | |
| chr9:133,534,455–133,535,168 | 55.6 kb | Distal (>10kb) Multiome | 295 | |
| chr9:133,608,924–133,609,730 | 130.3 kb | Distal (>10kb) Multiome | 411 | |
| chr9:133,738,059–133,738,688 | 259.2 kb | Distal (>10kb) Multiome | 451 |
Genomic view of the SLC2A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.