Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for SLC2A14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC2A14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC2A14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:7,638,028–7,638,994 | 234.5 kb | Distal (>10kb) Multiome | 360 | |
| chr12:7,639,859–7,640,636 | 232.9 kb | Distal (>10kb) Multiome | 28 | |
| chr12:7,709,770–7,710,489 | 163.2 kb | Distal (>10kb) Multiome | 82 | |
| chr12:7,859,953–7,860,905 | 12.9 kb | Distal (>10kb) Multiome HiCAR | 344 | |
| chr12:7,906,949–7,907,466 | 34.0 kb | Distal (>10kb) Multiome HiCAR | 435 | |
| chr12:7,935,022–7,936,948 | 63.1 kb | Distal (>10kb) Multiome | 450 | |
| chr12:7,937,904–7,938,471 | 64.9 kb | Distal (>10kb) Multiome | 193 | |
| chr12:7,959,506–7,960,170 | 86.6 kb | Distal (>10kb) Multiome | 284 | |
| chr12:7,960,785–7,961,174 | 87.7 kb | Distal (>10kb) Multiome | 471 | |
| chr12:7,970,302–7,971,168 | 97.6 kb | Distal (>10kb) Multiome | 619 | |
| chr12:7,994,878–7,995,556 | 122.0 kb | Distal (>10kb) Multiome | 262 | |
| chr12:8,018,686–8,019,483 | 145.8 kb | Distal (>10kb) Multiome | 217 | |
| chr12:8,026,338–8,027,323 | 153.6 kb | Distal (>10kb) Multiome | 935 | |
| chr12:8,032,354–8,033,866 | 159.5 kb | Distal (>10kb) Multiome | 673 | |
| chr12:8,081,804–8,082,716 | 208.9 kb | Distal (>10kb) Multiome | 840 |
Genomic view of the SLC2A14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.