This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
Transcription factors with Perturb-seq knockdown data for SLC27A4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC27A4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC27A4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,066,577–128,068,774 | 273.2 kb | Distal (>10kb) Multiome | 874 | |
| chr9:128,097,872–128,098,910 | 242.1 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 222.7 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 212.3 kb | Distal (>10kb) Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 180.4 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,191,300–128,192,050 | 148.9 kb | Distal (>10kb) Multiome | 865 | |
| chr9:128,203,004–128,204,704 | 136.1 kb | Distal (>10kb) Multiome | 690 | |
| chr9:128,218,656–128,219,107 | 121.6 kb | Distal (>10kb) Multiome | 410 | |
| chr9:128,250,012–128,251,099 | 90.0 kb | Distal (>10kb) Multiome | 353 | |
| chr9:128,275,636–128,276,535 | 64.5 kb | Distal (>10kb) Multiome | 728 | |
| chr9:128,322,183–128,322,933 | 17.9 kb | Distal (>10kb) Multiome | 962 | |
| chr9:128,340,070–128,341,161 | 55 bp | At TSS Multiome | 803 | |
| chr9:128,364,858–128,365,437 | 24.6 kb | Distal (>10kb) Multiome | 442 | |
| chr9:128,420,259–128,421,260 | 80.2 kb | Distal (>10kb) Multiome | 701 | |
| chr9:128,455,721–128,456,522 | 115.5 kb | Distal (>10kb) Multiome | 684 | |
| chr9:128,504,482–128,505,188 | 164.2 kb | Distal (>10kb) Multiome | 766 | |
| chr9:128,552,006–128,553,125 | 212.0 kb | Distal (>10kb) Multiome | 839 |
Genomic view of the SLC27A4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.