SLC27A1
solute carrier family 27 member 1 | ACSVL5, FATP, FATP1, FLJ00336, MGC71751

Enables biotin transmembrane transporter activity; efflux transmembrane transporter activity; and long-chain fatty acid transmembrane transporter activity. Involved in export across plasma membrane; lipid transport across blood-brain barrier; and monocarboxylic acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC6
Biological processes 54 terms
arachidonate-CoA ligase activity (GO:0047676)basal plasma membrane (GO:0009925)basal plasma membrane (GO:0009925)biotin import across plasma membrane (GO:1905135)biotin transmembrane transporter activity (GO:0015225)biotin transport (GO:0015878)cytoplasm (GO:0005737)efflux transmembrane transporter activity (GO:0015562)efflux transmembrane transporter activity (GO:0015562)endomembrane system (GO:0012505)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)export across plasma membrane (GO:0140115)export across plasma membrane (GO:0140115)fatty acid transmembrane transporter activity (GO:0015245)fatty acid transmembrane transporter activity (GO:0015245)glucose import in response to insulin stimulus (GO:0044381)glucose import in response to insulin stimulus (GO:0044381)identical protein binding (GO:0042802)lipid transport across blood-brain barrier (GO:1990379)lipid transport across blood-brain barrier (GO:1990379)long-chain fatty acid import across plasma membrane (GO:0015911)long-chain fatty acid import across plasma membrane (GO:0015911)long-chain fatty acid import into cell (GO:0044539)long-chain fatty acid import into cell (GO:0044539)long-chain fatty acid import into cell (GO:0044539)long-chain fatty acid import into cell (GO:0044539)long-chain fatty acid metabolic process (GO:0001676)long-chain fatty acid transmembrane transporter activity (GO:0005324)long-chain fatty acid transmembrane transporter activity (GO:0005324)long-chain fatty acid transmembrane transporter activity (GO:0005324)long-chain fatty acid transmembrane transporter activity (GO:0005324)long-chain fatty acid transport (GO:0015909)long-chain fatty acid transport (GO:0015909)long-chain fatty acid transport (GO:0015909)long-chain fatty acid-CoA ligase activity (GO:0004467)long-chain fatty acid-CoA ligase activity (GO:0004467)medium-chain fatty acid transport (GO:0001579)membrane (GO:0016020)membrane (GO:0016020)oleoyl-CoA ligase activity (GO:0090434)oleoyl-CoA ligase activity (GO:0090434)oleoyl-CoA ligase activity (GO:0090434)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of triglyceride biosynthetic process (GO:0010867)positive regulation of triglyceride biosynthetic process (GO:0010867)protein binding (GO:0005515)protein serine/threonine kinase activator activity (GO:0043539)transport across blood-brain barrier (GO:0150104)very long-chain fatty acid-CoA ligase activity (GO:0031957)
Expression (TPM)
SLC27A1 — as a Regulated Gene

TFs regulating SLC27A1 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC27A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC27A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SLC27A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC27A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:17,209,430–17,210,427 260.7 kb Distal (>10kb) Multiome 245
chr19:17,215,005–17,215,979 255.0 kb Distal (>10kb) Multiome 897
chr19:17,225,705–17,226,889 244.1 kb Distal (>10kb) Multiome 870
chr19:17,234,748–17,236,650 234.6 kb Distal (>10kb) Multiome 612
chr19:17,244,882–17,247,104 224.4 kb Distal (>10kb) Multiome 862
chr19:17,247,935–17,248,860 221.9 kb Distal (>10kb) Multiome 588
chr19:17,266,931–17,267,755 203.2 kb Distal (>10kb) Multiome 720
chr19:17,281,537–17,283,120 187.7 kb Distal (>10kb) Multiome 669
chr19:17,292,242–17,293,049 177.8 kb Distal (>10kb) Multiome 513
chr19:17,302,721–17,303,771 167.0 kb Distal (>10kb) Multiome 636
chr19:17,305,286–17,306,514 164.8 kb Distal (>10kb) Multiome 947
chr19:17,309,159–17,310,151 161.0 kb Distal (>10kb) Multiome 741
chr19:17,327,532–17,329,548 142.5 kb Distal (>10kb) Multiome 370
chr19:17,334,287–17,335,052 135.7 kb Distal (>10kb) Multiome 870
chr19:17,336,574–17,338,240 133.0 kb Distal (>10kb) Multiome 924
chr19:17,340,311–17,341,226 129.8 kb Distal (>10kb) Multiome 419
chr19:17,390,414–17,391,521 79.3 kb Distal (>10kb) Multiome 615
chr19:17,394,998–17,395,433 75.2 kb Distal (>10kb) Multiome 403
chr19:17,398,863–17,399,537 71.3 kb Distal (>10kb) Multiome 132
chr19:17,403,087–17,404,355 67.0 kb Distal (>10kb) Multiome 211
chr19:17,419,503–17,420,821 50.5 kb Distal (>10kb) Multiome 869
chr19:17,424,865–17,425,411 45.4 kb Distal (>10kb) Multiome 328
chr19:17,448,174–17,448,841 21.8 kb Distal (>10kb) Multiome 392
chr19:17,466,100–17,466,530 4.0 kb Proximal (<10kb) 169
chr19:17,468,858–17,470,905 370 bp At TSS Multiome 743
chr19:17,488,739–17,489,689 18.7 kb Distal (>10kb) Multiome 381
chr19:17,511,113–17,512,592 41.0 kb Distal (>10kb) Multiome 1021
chr19:17,538,878–17,540,353 69.3 kb Distal (>10kb) Multiome 725
chr19:17,555,194–17,556,523 85.1 kb Distal (>10kb) Multiome 713
chr19:17,576,463–17,577,455 106.5 kb Distal (>10kb) Multiome 236
chr19:17,579,580–17,580,242 109.5 kb Distal (>10kb) Multiome 281
chr19:17,605,468–17,607,009 135.7 kb Distal (>10kb) Multiome 1030
chr19:17,686,280–17,688,656 216.3 kb Distal (>10kb) Multiome 586
chr19:17,719,144–17,719,957 249.0 kb Distal (>10kb) Multiome 585
chr19:17,747,227–17,748,170 277.2 kb Distal (>10kb) Multiome 503
chr19:17,762,487–17,762,985 292.2 kb Distal (>10kb) Multiome 199

Genome Browser

Genomic view of the SLC27A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:17,199,430 – 17,772,985
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq