This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for SLC26A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC26A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC26A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:103,148,730–103,149,910 | 296.8 kb | Distal (>10kb) Multiome | 1002 | |
| chr7:103,279,769–103,280,793 | 165.7 kb | Distal (>10kb) Multiome | 291 | |
| chr7:103,297,040–103,297,853 | 148.7 kb | Distal (>10kb) Multiome | 880 | |
| chr7:103,344,148–103,345,138 | 101.4 kb | Distal (>10kb) Multiome | 994 | |
| chr7:103,347,517–103,348,162 | 98.4 kb | Distal (>10kb) Multiome | 795 | |
| chr7:103,445,161–103,446,559 | 75 bp | At TSS Multiome | 424 | |
| chr7:103,447,164–103,447,625 | 1.0 kb | Proximal (<10kb) | 265 | |
| chr7:103,597,491–103,598,216 | 151.7 kb | Distal (>10kb) Multiome | 73 | |
| chr7:104,126,183–104,126,930 | 680.5 kb | Distal (>10kb) Multiome HiCAR | 244 |
Genomic view of the SLC26A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.