This gene encodes a mitochondrial solute carrier protein family member. It functions in promoting mitochondrial fission, and prevents the formation of hyperfilamentous mitochondria. Mutation of this gene results in neuropathy and optic atrophy. [provided by RefSeq, Aug 2016]
Transcription factors with Perturb-seq knockdown data for SLC25A46. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A46 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A46, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:110,533,847–110,535,524 | 203.8 kb | Distal (>10kb) Multiome | 148 | |
| chr5:110,535,777–110,537,016 | 202.5 kb | Distal (>10kb) Multiome | 208 | |
| chr5:110,726,240–110,727,348 | 12.3 kb | Distal (>10kb) Multiome | 287 | |
| chr5:110,738,135–110,739,635 | 112 bp | At TSS Multiome | 896 | |
| chr5:110,757,036–110,757,410 | 3.7 kb | Proximal (<10kb) | 154 | |
| chr5:111,069,762–111,071,332 | 331.7 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr5:111,072,593–111,073,857 | 334.2 kb | Distal (>10kb) Multiome HiCAR | 461 |
Genomic view of the SLC25A46 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.