This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for SLC25A42. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A42 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A42, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:18,831,386–18,833,070 | 274.0 kb | Distal (>10kb) Multiome | 833 | |
| chr19:18,870,063–18,870,526 | 235.4 kb | Distal (>10kb) Multiome | 148 | |
| chr19:18,895,036–18,896,591 | 209.7 kb | Distal (>10kb) Multiome | 554 | |
| chr19:18,918,971–18,919,972 | 186.3 kb | Distal (>10kb) Multiome | 828 | |
| chr19:18,932,038–18,933,012 | 173.3 kb | Distal (>10kb) Multiome | 312 | |
| chr19:18,940,835–18,941,417 | 164.6 kb | Distal (>10kb) Multiome | 336 | |
| chr19:19,017,061–19,017,561 | 88.6 kb | Distal (>10kb) Multiome | 21 | |
| chr19:19,032,820–19,034,059 | 72.2 kb | Distal (>10kb) Multiome | 944 | |
| chr19:19,063,253–19,064,386 | 42.1 kb | Distal (>10kb) Multiome | 781 | |
| chr19:19,105,310–19,106,514 | 136 bp | At TSS Multiome | 447 | |
| chr19:19,110,429–19,110,857 | 4.8 kb | Proximal (<10kb) Multiome | 131 | |
| chr19:19,119,998–19,121,362 | 14.7 kb | Distal (>10kb) Multiome | 304 | |
| chr19:19,138,171–19,138,698 | 32.6 kb | Distal (>10kb) Multiome | 642 | |
| chr19:19,170,055–19,170,692 | 64.5 kb | Distal (>10kb) Multiome | 403 | |
| chr19:19,191,912–19,193,209 | 86.7 kb | Distal (>10kb) Multiome | 939 | |
| chr19:19,202,895–19,203,773 | 97.6 kb | Distal (>10kb) Multiome | 599 | |
| chr19:19,224,938–19,225,553 | 119.4 kb | Distal (>10kb) Multiome | 646 | |
| chr19:19,261,403–19,261,973 | 155.8 kb | Distal (>10kb) Multiome | 205 | |
| chr19:19,272,869–19,273,464 | 167.3 kb | Distal (>10kb) Multiome | 236 | |
| chr19:19,320,030–19,321,531 | 214.8 kb | Distal (>10kb) Multiome | 839 | |
| chr19:19,384,944–19,386,424 | 279.7 kb | Distal (>10kb) Multiome | 788 | |
| chr19:19,405,072–19,406,890 | 299.8 kb | Distal (>10kb) Multiome | 1014 |
Genomic view of the SLC25A42 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.