The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC25A3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:98,344,774–98,345,967 | 248.2 kb | Distal (>10kb) Multiome | 190 | |
| chr12:98,397,273–98,398,042 | 196.0 kb | Distal (>10kb) Multiome | 455 | |
| chr12:98,456,620–98,457,422 | 136.6 kb | Distal (>10kb) Multiome | 319 | |
| chr12:98,490,969–98,491,482 | 102.5 kb | Distal (>10kb) Multiome | 594 | |
| chr12:98,492,249–98,493,469 | 100.7 kb | Distal (>10kb) Multiome | 235 | |
| chr12:98,502,866–98,504,417 | 89.9 kb | Distal (>10kb) Multiome | 1073 | |
| chr12:98,515,010–98,516,657 | 78.1 kb | Distal (>10kb) Multiome | 999 | |
| chr12:98,593,166–98,594,492 | 43 bp | At TSS Multiome | 874 | |
| chr12:98,644,115–98,645,908 | 51.4 kb | Distal (>10kb) Multiome HiCAR | 906 | |
| chr12:98,696,171–98,696,840 | 102.9 kb | Distal (>10kb) Multiome | 204 | |
| chr12:98,735,936–98,737,224 | 143.3 kb | Distal (>10kb) Multiome | 226 | |
| chr12:100,199,080–100,201,296 | 1606.1 kb | Distal (>10kb) Multiome HiCAR | 955 |
Genomic view of the SLC25A3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.