The protein encoded by this gene belongs to the family of calcium-binding mitochondrial carriers, with a characteristic mitochondrial carrier domain at the C-terminus. These proteins are found in the inner membranes of mitochondria, and function as transport proteins. They shuttle metabolites, nucleotides and cofactors through the mitochondrial membrane and thereby connect and/or regulate cytoplasm and matrix functions. This protein may function as an ATP-Mg/Pi carrier that mediates the transport of Mg-ATP in exchange for phosphate, and likely responsible for the net uptake or efflux of adenine nucleotides into or from the mitochondria. Alternatively spliced transcript variants encoding different isoforms with a common C-terminus but variable N-termini have been described for this gene. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for SLC25A25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,770,807–127,771,925 | 296.7 kb | Distal (>10kb) Multiome | 550 | |
| chr9:127,784,682–127,787,009 | 281.6 kb | Distal (>10kb) Multiome | 858 | |
| chr9:127,802,385–127,803,632 | 265.3 kb | Distal (>10kb) Multiome | 867 | |
| chr9:127,809,338–127,810,272 | 258.3 kb | Distal (>10kb) Multiome | 276 | |
| chr9:127,825,222–127,826,046 | 242.6 kb | Distal (>10kb) Multiome | 451 | |
| chr9:127,828,234–127,829,024 | 239.6 kb | Distal (>10kb) Multiome | 521 | |
| chr9:127,877,282–127,878,202 | 190.4 kb | Distal (>10kb) Multiome | 531 | |
| chr9:127,897,316–127,897,796 | 170.7 kb | Distal (>10kb) Multiome | 437 | |
| chr9:127,898,861–127,900,094 | 168.6 kb | Distal (>10kb) Multiome | 630 | |
| chr9:127,916,386–127,917,505 | 151.1 kb | Distal (>10kb) Multiome | 474 | |
| chr9:127,926,756–127,928,574 | 140.7 kb | Distal (>10kb) Multiome | 411 | |
| chr9:127,930,321–127,931,068 | 137.4 kb | Distal (>10kb) Multiome HiCAR | 537 | |
| chr9:127,937,578–127,938,244 | 130.3 kb | Distal (>10kb) Multiome HiCAR | 674 | |
| chr9:127,955,445–127,955,915 | 112.6 kb | Distal (>10kb) Multiome HiCAR | 540 | |
| chr9:127,980,172–127,981,966 | 87.1 kb | Distal (>10kb) Multiome | 691 | |
| chr9:128,033,544–128,034,106 | 34.3 kb | Distal (>10kb) Multiome | 69 | |
| chr9:128,034,940–128,035,527 | 32.9 kb | Distal (>10kb) Multiome | 480 | |
| chr9:128,058,149–128,058,453 | 9.7 kb | Proximal (<10kb) | 143 | |
| chr9:128,066,577–128,068,774 | 833 bp | At TSS Multiome | 874 | |
| chr9:128,097,872–128,098,910 | 30.2 kb | Distal (>10kb) Multiome | 712 | |
| chr9:128,117,658–128,118,328 | 49.7 kb | Distal (>10kb) Multiome | 640 | |
| chr9:128,127,314–128,128,793 | 60.1 kb | Distal (>10kb) Multiome | 899 | |
| chr9:128,159,371–128,160,928 | 91.9 kb | Distal (>10kb) Multiome | 824 | |
| chr9:128,191,300–128,192,050 | 123.5 kb | Distal (>10kb) Multiome | 865 | |
| chr9:128,203,004–128,204,704 | 136.2 kb | Distal (>10kb) Multiome | 690 | |
| chr9:128,218,656–128,219,107 | 150.7 kb | Distal (>10kb) Multiome | 410 | |
| chr9:128,250,012–128,251,099 | 182.3 kb | Distal (>10kb) Multiome | 353 | |
| chr9:128,275,636–128,276,535 | 207.9 kb | Distal (>10kb) Multiome | 728 | |
| chr9:128,322,183–128,322,933 | 254.4 kb | Distal (>10kb) Multiome | 962 | |
| chr9:128,340,070–128,341,161 | 272.3 kb | Distal (>10kb) Multiome | 803 | |
| chr9:128,364,858–128,365,437 | 296.9 kb | Distal (>10kb) Multiome | 442 |
Genomic view of the SLC25A25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.