This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Transcription factors with Perturb-seq knockdown data for SLC25A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC25A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC25A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:18,970,147–18,971,015 | 208.1 kb | Distal (>10kb) Multiome | 277 | |
| chr22:19,116,923–19,117,513 | 61.3 kb | Distal (>10kb) Multiome | 54 | |
| chr22:19,121,544–19,123,310 | 55.9 kb | Distal (>10kb) Multiome | 690 | |
| chr22:19,144,380–19,144,950 | 33.7 kb | Distal (>10kb) Multiome | 696 | |
| chr22:19,149,463–19,150,252 | 28.8 kb | Distal (>10kb) Multiome | 173 | |
| chr22:19,169,265–19,169,982 | 8.8 kb | Proximal (<10kb) Multiome | 285 | |
| chr22:19,170,964–19,172,196 | 6.8 kb | Proximal (<10kb) Multiome | 819 | |
| chr22:19,177,562–19,180,087 | 357 bp | At TSS Multiome | 875 | |
| chr22:19,290,875–19,292,389 | 113.3 kb | Distal (>10kb) Multiome | 854 | |
| chr22:19,431,488–19,432,799 | 253.9 kb | Distal (>10kb) Multiome | 1140 | |
| chr22:19,446,962–19,448,379 | 269.2 kb | Distal (>10kb) Multiome | 889 |
Genomic view of the SLC25A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.