This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for SLC22A18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC22A18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC22A18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:2,420,598–2,421,164 | 481.4 kb | Distal (>10kb) Multiome HiCAR | 385 | |
| chr11:2,532,598–2,533,458 | 369.3 kb | Distal (>10kb) Multiome HiCAR | 567 | |
| chr11:2,693,272–2,694,189 | 208.8 kb | Distal (>10kb) Multiome | 236 | |
| chr11:2,699,491–2,700,586 | 202.1 kb | Distal (>10kb) Multiome | 879 | |
| chr11:2,862,328–2,863,500 | 39.7 kb | Distal (>10kb) Multiome | 132 | |
| chr11:2,883,795–2,886,948 | 16.3 kb | Distal (>10kb) Multiome | 639 | |
| chr11:2,891,828–2,893,111 | 9.8 kb | Proximal (<10kb) Multiome | 572 | |
| chr11:2,901,621–2,903,073 | 94 bp | At TSS Multiome | 610 | |
| chr11:2,928,807–2,931,249 | 28.6 kb | Distal (>10kb) Multiome | 770 | |
| chr11:2,991,519–2,993,201 | 90.1 kb | Distal (>10kb) Multiome | 759 | |
| chr11:3,056,953–3,057,972 | 155.3 kb | Distal (>10kb) Multiome | 798 | |
| chr11:3,091,645–3,092,317 | 189.7 kb | Distal (>10kb) Multiome | 449 | |
| chr11:3,148,512–3,149,454 | 246.7 kb | Distal (>10kb) Multiome | 152 | |
| chr11:3,160,043–3,161,026 | 258.2 kb | Distal (>10kb) Multiome | 283 | |
| chr11:3,164,925–3,165,485 | 263.0 kb | Distal (>10kb) Multiome | 326 |
Genomic view of the SLC22A18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.