Organic ion transporters, such as SLC22A15, transport various medically and physiologically important compounds, including pharmaceuticals, toxins, hormones, neurotransmitters, and cellular metabolites. These transporters are also referred to as amphiphilic solute facilitators (ASFs).[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for SLC22A15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC22A15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC22A15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:115,771,492–115,772,197 | 204.6 kb | Distal (>10kb) Multiome | 355 | |
| chr1:115,828,121–115,829,682 | 147.8 kb | Distal (>10kb) Multiome HiCAR | 408 | |
| chr1:115,837,650–115,839,828 | 138.5 kb | Distal (>10kb) Multiome HiCAR | 304 | |
| chr1:115,924,342–115,925,363 | 51.6 kb | Distal (>10kb) Multiome | 172 | |
| chr1:115,969,536–115,969,823 | 6.7 kb | Proximal (<10kb) | 128 | |
| chr1:115,975,977–115,977,205 | 4 bp | At TSS Multiome | 536 | |
| chr1:115,981,268–115,981,725 | 4.8 kb | Proximal (<10kb) | 140 | |
| chr1:116,138,890–116,139,376 | 162.7 kb | Distal (>10kb) Multiome | 625 | |
| chr1:116,151,870–116,152,550 | 175.7 kb | Distal (>10kb) Multiome | 538 | |
| chr1:116,167,654–116,168,661 | 191.9 kb | Distal (>10kb) Multiome | 379 |
Genomic view of the SLC22A15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.