SLC1A6
solute carrier family 1 member 6 | EAAT4

Enables L-aspartate transmembrane transporter activity; L-glutamate transmembrane transporter activity; and glutamate:sodium symporter activity. Involved in L-aspartate import across plasma membrane; L-glutamate import across plasma membrane; and neurotransmitter uptake. Located in intermediate filament cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC4
Biological processes 38 terms
Golgi apparatus (GO:0005794)L-aspartate import across plasma membrane (GO:0140009)L-aspartate transmembrane transporter activity (GO:0015183)L-aspartate transmembrane transporter activity (GO:0015183)L-glutamate import across plasma membrane (GO:0098712)L-glutamate import across plasma membrane (GO:0098712)L-glutamate transmembrane transport (GO:0015813)L-glutamate transmembrane transport (GO:0015813)L-glutamate transmembrane transporter activity (GO:0005313)L-glutamate transmembrane transporter activity (GO:0005313)L-glutamate transmembrane transporter activity (GO:0005313)amino acid transport (GO:0006865)aspartate transmembrane transport (GO:0015810)chemical synaptic transmission (GO:0007268)glutamate:sodium symporter activity (GO:0015501)glutamate:sodium symporter activity (GO:0015501)glutamate:sodium symporter activity (GO:0015501)glutamatergic synapse (GO:0098978)high-affinity L-glutamate transmembrane transporter activity (GO:0005314)high-affinity L-glutamate transmembrane transporter activity (GO:0005314)import into cell (GO:0098657)membrane (GO:0016020)membrane (GO:0016020)membrane protein complex (GO:0098796)neurotransmitter transport (GO:0006836)neurotransmitter transport (GO:0006836)neurotransmitter uptake (GO:0001504)neurotransmitter uptake (GO:0001504)neurotransmitter uptake (GO:0001504)neutral L-amino acid transmembrane transporter activity (GO:0015175)neutral amino acid transport (GO:0015804)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)presynaptic membrane (GO:0042734)symporter activity (GO:0015293)
Expression (TPM)
SLC1A6 — as a Regulated Gene

TFs regulating SLC1A6 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC1A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC1A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to SLC1A6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC1A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:14,689,407–14,690,497 289.9 kb Distal (>10kb) Multiome 624
chr19:14,979,199–14,980,219 22 bp At TSS Multiome 147
chr19:15,010,607–15,011,356 31.1 kb Distal (>10kb) Multiome 122
chr19:15,106,942–15,107,576 127.4 kb Distal (>10kb) Multiome 339
chr19:15,113,323–15,113,828 133.7 kb Distal (>10kb) Multiome 116
chr19:15,124,546–15,126,107 145.8 kb Distal (>10kb) Multiome 949
chr19:15,177,520–15,178,026 197.8 kb Distal (>10kb) Multiome 499
chr19:15,180,886–15,181,623 201.3 kb Distal (>10kb) Multiome 355
chr19:15,195,187–15,196,375 216.2 kb Distal (>10kb) Multiome 408
chr19:15,199,629–15,201,437 221.3 kb Distal (>10kb) Multiome 398
chr19:15,222,727–15,224,168 243.5 kb Distal (>10kb) Multiome 521
chr19:15,231,632–15,233,858 253.4 kb Distal (>10kb) Multiome 414

Genome Browser

Genomic view of the SLC1A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:14,679,407 – 15,243,858
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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