The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for SLC19A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC19A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC19A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:45,286,648–45,288,846 | 253.8 kb | Distal (>10kb) Multiome | 708 | |
| chr21:45,292,336–45,292,948 | 249.2 kb | Distal (>10kb) Multiome | 599 | |
| chr21:45,403,955–45,406,352 | 136.8 kb | Distal (>10kb) Multiome | 551 | |
| chr21:45,541,804–45,541,965 | at TSS | At TSS | 532 | |
| chr21:45,542,344–45,542,711 | 506 bp | At TSS | 344 | |
| chr21:45,555,336–45,556,476 | 14.2 kb | Distal (>10kb) Multiome | 868 | |
| chr21:45,642,064–45,644,410 | 101.5 kb | Distal (>10kb) Multiome | 420 |
Genomic view of the SLC19A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.