SLC18A2

solute carrier family 18 member A2 | SVAT, SVMT, VAT2, VMAT2

This gene encodes an transmembrane protein that functions as an ATP-dependent transporter of monoamines, such as dopamine, norepinephrine, serotonin, and histamine. This protein transports amine neurotransmitters into synaptic vesicles. Polymorphisms in this gene may be associated with schizophrenia, bipolar disorder, and other neurological/psychiatric ailments. [provided by RefSeq, Jun 2018]

Developmental clusters: GC4

Biological processes 41 terms

aminergic neurotransmitter loading into synaptic vesicle (GO:0015842)axon (GO:0030424)axon (GO:0030424)chemical synaptic transmission (GO:0007268)clathrin-sculpted monoamine transport vesicle membrane (GO:0070083)clathrin-sculpted monoamine transport vesicle membrane (GO:0070083)dendrite (GO:0030425)dendrite (GO:0030425)dopamine transport (GO:0015872)dopamine transport (GO:0015872)dopaminergic synapse (GO:0098691)establishment of localization in cell (GO:0051649)histamine secretion by mast cell (GO:0002553)histamine uptake (GO:0051615)membrane (GO:0016020)monoamine transmembrane transporter activity (GO:0008504)monoamine transport (GO:0015844)monoamine:proton antiporter activity (GO:0015311)negative regulation of reactive oxygen species biosynthetic process (GO:1903427)neurotransmitter loading into synaptic vesicle (GO:0098700)neurotransmitter loading into synaptic vesicle (GO:0098700)neurotransmitter loading into synaptic vesicle (GO:0098700)neurotransmitter transport (GO:0006836)neurotransmitter transport (GO:0006836)plasma membrane (GO:0005886)protein binding (GO:0005515)proton transmembrane transport (GO:1902600)secretory granule membrane (GO:0030667)serotonin secretion by mast cell (GO:0002552)serotonin transport (GO:0006837)serotonin uptake (GO:0051610)serotonin:sodium:chloride symporter activity (GO:0005335)somato-dendritic dopamine secretion (GO:0099123)synaptic vesicle (GO:0008021)synaptic vesicle membrane (GO:0030672)synaptic vesicle membrane (GO:0030672)synaptic vesicle membrane (GO:0030672)terminal bouton (GO:0043195)transmembrane transport (GO:0055085)transmembrane transporter activity (GO:0022857)transport vesicle membrane (GO:0030658)

Expression (TPM)

TFs regulating SLC18A2 0 TFs

Transcription factors with Perturb-seq knockdown data for SLC18A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC18A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SLC18A2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC18A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:117,004,546–117,006,106	235.9 kb	Distal (>10kb) Multiome	880
chr10:117,134,080–117,135,217	106.5 kb	Distal (>10kb) Multiome	216
chr10:117,136,768–117,138,029	103.9 kb	Distal (>10kb) Multiome	337
chr10:117,159,202–117,159,932	81.5 kb	Distal (>10kb) Multiome	133
chr10:117,162,523–117,164,008	78.0 kb	Distal (>10kb) Multiome	315
chr10:117,165,627–117,166,409	75.1 kb	Distal (>10kb) Multiome	272
chr10:117,167,701–117,168,673	72.8 kb	Distal (>10kb) Multiome	441
chr10:117,216,481–117,217,759	24.3 kb	Distal (>10kb) Multiome	688
chr10:117,240,160–117,242,055	115 bp	At TSS Multiome	361
chr10:117,346,576–117,347,199	105.7 kb	Distal (>10kb) Multiome	109
chr10:117,374,572–117,376,277	134.4 kb	Distal (>10kb) Multiome	881

Genome Browser

Genomic view of the SLC18A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.