This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC17A5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC17A5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC17A5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:73,388,539–73,389,752 | 264.9 kb | Distal (>10kb) Multiome | 579 | |
| chr6:73,450,878–73,452,652 | 201.9 kb | Distal (>10kb) Multiome | 510 | |
| chr6:73,461,207–73,462,355 | 192.3 kb | Distal (>10kb) Multiome | 806 | |
| chr6:73,511,142–73,516,574 | 139.7 kb | Distal (>10kb) Multiome | 913 | |
| chr6:73,520,105–73,522,117 | 132.7 kb | Distal (>10kb) Multiome HiCAR | 1220 | |
| chr6:73,579,484–73,580,917 | 73.5 kb | Distal (>10kb) Multiome | 828 | |
| chr6:73,645,431–73,645,820 | 8.2 kb | Proximal (<10kb) | 52 | |
| chr6:73,653,023–73,654,818 | 16 bp | At TSS Multiome | 944 | |
| chr6:73,695,662–73,696,526 | 42.1 kb | Distal (>10kb) Multiome | 534 | |
| chr6:75,243,188–75,244,541 | 1589.8 kb | Distal (>10kb) Multiome HiCAR | 858 | |
| chr6:75,283,886–75,285,703 | 1630.9 kb | Distal (>10kb) Multiome HiCAR | 948 | |
| chr6:75,348,793–75,350,207 | 1695.6 kb | Distal (>10kb) Multiome HiCAR | 378 | |
| chr6:75,601,534–75,603,064 | 1948.0 kb | Distal (>10kb) Multiome HiCAR | 930 |
Genomic view of the SLC17A5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.