SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
Transcription factors with Perturb-seq knockdown data for SLC16A8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC16A8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC16A8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,802,124–37,802,989 | 281.7 kb | Distal (>10kb) Multiome | 603 | |
| chr22:37,804,679–37,805,768 | 278.9 kb | Distal (>10kb) Multiome | 763 | |
| chr22:37,807,436–37,808,267 | 276.3 kb | Distal (>10kb) Multiome | 766 | |
| chr22:37,817,672–37,819,114 | 266.2 kb | Distal (>10kb) Multiome | 713 | |
| chr22:37,824,524–37,825,593 | 259.1 kb | Distal (>10kb) Multiome | 173 | |
| chr22:37,843,748–37,844,743 | 239.7 kb | Distal (>10kb) Multiome | 798 | |
| chr22:37,849,215–37,849,709 | 234.7 kb | Distal (>10kb) Multiome | 753 | |
| chr22:37,905,849–37,906,846 | 177.8 kb | Distal (>10kb) Multiome | 552 | |
| chr22:37,933,777–37,934,256 | 150.0 kb | Distal (>10kb) Multiome | 679 | |
| chr22:37,953,153–37,954,120 | 130.4 kb | Distal (>10kb) Multiome | 617 | |
| chr22:37,983,021–37,985,110 | 99.7 kb | Distal (>10kb) Multiome | 228 | |
| chr22:38,052,312–38,052,803 | 31.6 kb | Distal (>10kb) Multiome | 529 | |
| chr22:38,057,008–38,057,702 | 26.8 kb | Distal (>10kb) Multiome | 656 | |
| chr22:38,080,912–38,081,618 | 3.0 kb | Proximal (<10kb) Multiome | 175 | |
| chr22:38,097,697–38,098,236 | 13.9 kb | Distal (>10kb) Multiome | 186 | |
| chr22:38,181,365–38,182,291 | 97.8 kb | Distal (>10kb) Multiome | 676 | |
| chr22:38,201,378–38,203,636 | 117.8 kb | Distal (>10kb) Multiome | 848 | |
| chr22:38,214,397–38,215,017 | 130.7 kb | Distal (>10kb) Multiome | 382 | |
| chr22:38,272,379–38,273,237 | 188.9 kb | Distal (>10kb) Multiome | 526 | |
| chr22:38,317,171–38,317,940 | 233.3 kb | Distal (>10kb) Multiome | 524 | |
| chr22:38,319,024–38,319,874 | 235.5 kb | Distal (>10kb) Multiome | 181 | |
| chr22:38,335,940–38,336,726 | 252.2 kb | Distal (>10kb) Multiome | 297 | |
| chr22:38,353,217–38,354,166 | 269.4 kb | Distal (>10kb) Multiome | 404 |
Genomic view of the SLC16A8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.