This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for SLC16A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC16A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC16A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:74,249,927–74,250,404 | 171.3 kb | Distal (>10kb) Multiome | 183 | |
| chrX:74,259,954–74,260,568 | 161.3 kb | Distal (>10kb) Multiome | 106 | |
| chrX:74,292,249–74,293,905 | 129.0 kb | Distal (>10kb) Multiome | 594 | |
| chrX:74,325,234–74,326,322 | 95.8 kb | Distal (>10kb) Multiome | 229 | |
| chrX:74,419,854–74,421,997 | 995 bp | At TSS Multiome | 370 | |
| chrX:74,422,455–74,423,310 | 1.5 kb | Proximal (<10kb) Multiome | 202 | |
| chrX:74,535,197–74,537,347 | 115.2 kb | Distal (>10kb) Multiome | 425 | |
| chrX:74,614,086–74,615,093 | 193.2 kb | Distal (>10kb) Multiome | 611 |
Genomic view of the SLC16A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.