This gene encodes a transmembrane transporter that likely plays a role in monocarboxylic acid transport. A mutation in this gene has been associated with juvenile cataracts with microcornea and renal glucosuria. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for SLC16A12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC16A12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC16A12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:89,251,129–89,252,212 | 283.7 kb | Distal (>10kb) Multiome | 665 | |
| chr10:89,260,204–89,260,902 | 275.0 kb | Distal (>10kb) Multiome | 392 | |
| chr10:89,333,420–89,334,413 | 201.4 kb | Distal (>10kb) Multiome | 253 | |
| chr10:89,414,203–89,415,651 | 120.8 kb | Distal (>10kb) Multiome | 735 | |
| chr10:89,533,952–89,534,872 | 1.3 kb | Proximal (<10kb) Multiome | 254 | |
| chr10:89,535,099–89,536,715 | 135 bp | At TSS Multiome | 338 | |
| chr10:89,643,675–89,646,137 | 108.5 kb | Distal (>10kb) Multiome | 1058 | |
| chr10:89,701,088–89,702,002 | 165.9 kb | Distal (>10kb) Multiome | 944 |
Genomic view of the SLC16A12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.