This gene encodes a protein that binds to the stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by endonucleolytic cleavage. The stem-loop structure is essential for efficient processing but this structure also controls the transport, translation and stability of histone mRNAs. Expression of the protein is regulated during the cell cycle, increasing more than 10-fold during the latter part of G1. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:1,512,763–1,513,500 | 199.1 kb | Distal (>10kb) Multiome | 317 | |
| chr4:1,578,390–1,579,916 | 133.1 kb | Distal (>10kb) Multiome | 472 | |
| chr4:1,580,022–1,580,836 | 131.7 kb | Distal (>10kb) Multiome | 412 | |
| chr4:1,683,721–1,685,162 | 27.9 kb | Distal (>10kb) Multiome | 624 | |
| chr4:1,711,443–1,713,255 | 195 bp | At TSS Multiome | 1043 | |
| chr4:1,720,066–1,721,937 | 9.0 kb | Proximal (<10kb) Multiome | 817 | |
| chr4:1,746,068–1,746,713 | 34.0 kb | Distal (>10kb) Multiome | 499 | |
| chr4:1,748,435–1,748,986 | 36.5 kb | Distal (>10kb) Multiome | 420 | |
| chr4:1,766,230–1,768,653 | 55.0 kb | Distal (>10kb) Multiome | 781 | |
| chr4:1,792,302–1,795,939 | 80.9 kb | Distal (>10kb) Multiome | 784 | |
| chr4:1,809,836–1,810,515 | 97.8 kb | Distal (>10kb) Multiome | 554 | |
| chr4:1,855,368–1,857,225 | 143.9 kb | Distal (>10kb) Multiome | 849 | |
| chr4:1,870,118–1,872,300 | 158.8 kb | Distal (>10kb) Multiome | 962 | |
| chr4:2,008,507–2,010,125 | 296.9 kb | Distal (>10kb) Multiome | 1040 |
Genomic view of the SLBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.