Involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Located in centrosome; cytosol; and microtubule plus-end. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLAIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLAIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLAIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:48,126,799–48,128,119 | 213.7 kb | Distal (>10kb) Multiome | 526 | |
| chr4:48,268,963–48,270,705 | 71.6 kb | Distal (>10kb) Multiome | 781 | |
| chr4:48,340,361–48,342,666 | 148 bp | At TSS Multiome | 962 | |
| chr4:48,345,197–48,345,336 | 3.7 kb | Proximal (<10kb) | 13 | |
| chr4:48,483,006–48,484,450 | 141.9 kb | Distal (>10kb) Multiome | 378 | |
| chr4:48,489,884–48,491,646 | 148.9 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the SLAIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.