This gene encodes a protein with twenty tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Mutations in this gene are associated with trichohepatoenteric syndrome. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for SKIC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SKIC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SKIC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:95,283,233–95,285,856 | 270.7 kb | Distal (>10kb) Multiome | 620 | |
| chr5:95,439,846–95,441,190 | 114.7 kb | Distal (>10kb) Multiome | 213 | |
| chr5:95,554,418–95,555,610 | 110 bp | At TSS Multiome | 886 | |
| chr5:95,619,877–95,621,756 | 66.4 kb | Distal (>10kb) Multiome | 693 | |
| chr5:95,646,204–95,647,493 | 91.9 kb | Distal (>10kb) Multiome | 938 | |
| chr5:95,668,883–95,670,237 | 114.6 kb | Distal (>10kb) Multiome | 232 | |
| chr5:95,707,140–95,707,835 | 152.6 kb | Distal (>10kb) Multiome | 297 | |
| chr5:95,710,009–95,710,708 | 155.5 kb | Distal (>10kb) Multiome | 190 | |
| chr5:95,710,983–95,712,019 | 156.7 kb | Distal (>10kb) Multiome | 238 | |
| chr5:95,730,766–95,732,378 | 176.3 kb | Distal (>10kb) Multiome | 1009 | |
| chr5:95,822,039–95,823,085 | 267.6 kb | Distal (>10kb) Multiome | 509 | |
| chr5:95,823,341–95,824,963 | 269.5 kb | Distal (>10kb) Multiome | 644 | |
| chr5:95,834,672–95,835,242 | 280.1 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the SKIC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.