SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]
Transcription factors with Perturb-seq knockdown data for SIRT3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIRT3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIRT3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:206,950–208,051 | 28.9 kb | Distal (>10kb) Multiome | 884 | |
| chr11:208,471–209,205 | 27.5 kb | Distal (>10kb) Multiome | 593 | |
| chr11:235,864–237,255 | 147 bp | At TSS Multiome | 874 | |
| chr11:288,466–289,320 | 52.7 kb | Distal (>10kb) Multiome | 400 | |
| chr11:313,383–314,476 | 77.5 kb | Distal (>10kb) Multiome | 421 | |
| chr11:316,978–318,064 | 80.8 kb | Distal (>10kb) Multiome | 100 | |
| chr11:333,722–334,610 | 97.9 kb | Distal (>10kb) Multiome | 238 | |
| chr11:355,654–356,479 | 119.9 kb | Distal (>10kb) Multiome | 894 | |
| chr11:370,037–370,556 | 133.8 kb | Distal (>10kb) Multiome | 205 | |
| chr11:406,008–408,661 | 170.9 kb | Distal (>10kb) Multiome | 587 | |
| chr11:416,764–417,613 | 181.0 kb | Distal (>10kb) Multiome | 431 | |
| chr11:447,919–448,752 | 211.9 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 213.9 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 270.8 kb | Distal (>10kb) Multiome | 977 | |
| chr11:534,525–536,399 | 299.3 kb | Distal (>10kb) Multiome | 673 |
Genomic view of the SIRT3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.