Involved in negative regulation of cell migration. Part of Sin3-type complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SINHCAF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SINHCAF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SINHCAF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:31,073,468–31,074,778 | 252.1 kb | Distal (>10kb) Multiome | 544 | |
| chr12:31,265,597–31,266,170 | 60.2 kb | Distal (>10kb) Multiome | 72 | |
| chr12:31,323,558–31,326,665 | 1.9 kb | Proximal (<10kb) Multiome | 943 | |
| chr12:31,346,903–31,347,737 | 21.1 kb | Distal (>10kb) Multiome | 105 | |
| chr12:31,362,120–31,363,072 | 36.4 kb | Distal (>10kb) Multiome | 485 | |
| chr12:31,368,619–31,369,388 | 42.9 kb | Distal (>10kb) Multiome | 173 | |
| chr12:31,370,717–31,371,181 | 44.9 kb | Distal (>10kb) Multiome | 293 | |
| chr12:31,589,796–31,591,586 | 264.9 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the SINHCAF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.