Predicted to enable several functions, including AP-1 adaptor complex binding activity; AP-2 adaptor complex binding activity; and RNA transmembrane transporter activity. Involved in RNA transport. Located in lysosomal membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SIDT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIDT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIDT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:116,772,462–116,773,416 | 405.8 kb | Distal (>10kb) Multiome HiCAR | 928 | |
| chr11:117,097,570–117,099,243 | 80.3 kb | Distal (>10kb) Multiome | 739 | |
| chr11:117,099,458–117,100,103 | 78.8 kb | Distal (>10kb) Multiome | 62 | |
| chr11:117,143,916–117,144,864 | 34.4 kb | Distal (>10kb) Multiome | 969 | |
| chr11:117,178,198–117,179,718 | 66 bp | At TSS Multiome | 726 | |
| chr11:117,181,326–117,181,571 | 2.6 kb | Proximal (<10kb) | 300 | |
| chr11:117,197,957–117,198,434 | 19.3 kb | Distal (>10kb) Multiome | 160 | |
| chr11:117,198,962–117,199,797 | 20.6 kb | Distal (>10kb) Multiome | 211 | |
| chr11:117,231,703–117,233,431 | 53.8 kb | Distal (>10kb) Multiome | 703 | |
| chr11:117,315,726–117,316,638 | 137.6 kb | Distal (>10kb) Multiome | 619 | |
| chr11:117,327,486–117,328,627 | 149.2 kb | Distal (>10kb) Multiome | 751 | |
| chr11:117,410,817–117,412,004 | 232.6 kb | Distal (>10kb) Multiome | 247 | |
| chr11:117,429,727–117,430,361 | 251.4 kb | Distal (>10kb) Multiome | 126 | |
| chr11:117,443,412–117,443,876 | 265.0 kb | Distal (>10kb) Multiome | 185 |
Genomic view of the SIDT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.