This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SIAH2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SIAH2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SIAH2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:150,545,562–150,547,264 | 216.6 kb | Distal (>10kb) Multiome | 992 | |
| chr3:150,599,511–150,600,247 | 163.2 kb | Distal (>10kb) Multiome | 405 | |
| chr3:150,602,900–150,604,229 | 159.9 kb | Distal (>10kb) Multiome | 999 | |
| chr3:150,703,274–150,704,319 | 59.3 kb | Distal (>10kb) Multiome | 674 | |
| chr3:150,761,779–150,762,204 | 964 bp | At TSS | 341 | |
| chr3:150,762,327–150,764,149 | 146 bp | At TSS Multiome | 953 | |
| chr3:150,766,033–150,766,420 | 2.9 kb | Proximal (<10kb) | 362 |
Genomic view of the SIAH2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.