SHQ1 assists in the assembly of H/ACA-box ribonucleoproteins that function in the processing of ribosomal RNAs, modification of spliceosomal small nuclear RNAs, and stabilization of telomerase (see MIM 602322) (Grozdanov et al., 2009 [PubMed 19383767]).[supplied by OMIM, Dec 2010]
Transcription factors with Perturb-seq knockdown data for SHQ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHQ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHQ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:71,724,579–71,725,985 | 1123.2 kb | Distal (>10kb) Multiome HiCAR | 430 | |
| chr3:71,925,496–71,926,501 | 922.0 kb | Distal (>10kb) Multiome HiCAR | 136 | |
| chr3:72,665,704–72,666,421 | 182.5 kb | Distal (>10kb) Multiome | 244 | |
| chr3:72,738,568–72,739,351 | 109.6 kb | Distal (>10kb) Multiome | 226 | |
| chr3:72,743,925–72,744,951 | 104.0 kb | Distal (>10kb) Multiome | 287 | |
| chr3:72,847,792–72,848,962 | 19 bp | At TSS Multiome | 806 | |
| chr3:72,887,818–72,888,647 | 39.7 kb | Distal (>10kb) Multiome | 512 | |
| chr3:72,972,793–72,973,464 | 124.7 kb | Distal (>10kb) Multiome | 324 | |
| chr3:72,996,248–72,997,607 | 148.3 kb | Distal (>10kb) Multiome | 749 |
Genomic view of the SHQ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.