Involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Located in site of double-strand break. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SHLD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHLD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHLD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:5,609,902–5,611,444 | 139.4 kb | Distal (>10kb) Multiome | 1005 | |
| chr20:5,750,092–5,750,988 | 85 bp | At TSS Multiome | 748 | |
| chr20:5,911,112–5,912,073 | 161.2 kb | Distal (>10kb) Multiome | 998 | |
| chr20:5,950,060–5,951,226 | 200.2 kb | Distal (>10kb) Multiome | 919 | |
| chr20:6,005,701–6,006,981 | 255.6 kb | Distal (>10kb) Multiome | 999 |
Genomic view of the SHLD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.