Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SHISAL2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHISAL2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHISAL2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:64,505,514–64,507,841 | 184.0 kb | Distal (>10kb) Multiome | 447 | |
| chr5:64,680,445–64,680,648 | 9.8 kb | Proximal (<10kb) | 31 | |
| chr5:64,682,658–64,683,013 | 7.4 kb | Proximal (<10kb) | 45 | |
| chr5:64,685,519–64,686,339 | 4.1 kb | Proximal (<10kb) | 28 | |
| chr5:64,688,859–64,689,430 | 1.0 kb | Proximal (<10kb) | 48 | |
| chr5:64,690,060–64,691,616 | 342 bp | At TSS Multiome | 408 | |
| chr5:64,705,728–64,706,826 | 15.8 kb | Distal (>10kb) Multiome | 254 | |
| chr5:64,744,765–64,745,704 | 54.7 kb | Distal (>10kb) Multiome | 169 | |
| chr5:64,760,120–64,760,918 | 70.1 kb | Distal (>10kb) Multiome HiCAR | 140 | |
| chr5:64,767,999–64,769,372 | 78.3 kb | Distal (>10kb) Multiome HiCAR | 909 | |
| chr5:65,562,647–65,563,667 | 872.8 kb | Distal (>10kb) Multiome HiCAR | 818 |
Genomic view of the SHISAL2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.