Enables phosphotyrosine residue binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including hematopoietic stem cell proliferation; negative regulation of oocyte maturation; and positive regulation of immune response. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SHB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:37,784,663–37,785,433 | 284.2 kb | Distal (>10kb) Multiome | 859 | |
| chr9:37,800,307–37,801,695 | 268.4 kb | Distal (>10kb) Multiome | 1104 | |
| chr9:37,903,405–37,904,985 | 165.0 kb | Distal (>10kb) Multiome | 1045 | |
| chr9:37,913,669–37,914,191 | 155.4 kb | Distal (>10kb) Multiome HiCAR | 509 | |
| chr9:37,922,396–37,923,788 | 145.9 kb | Distal (>10kb) Multiome HiCAR | 162 | |
| chr9:38,017,105–38,017,773 | 51.9 kb | Distal (>10kb) Multiome | 267 | |
| chr9:38,066,700–38,070,292 | 402 bp | At TSS Multiome | 922 | |
| chr9:38,107,683–38,108,797 | 39.0 kb | Distal (>10kb) Multiome | 259 | |
| chr9:38,154,485–38,155,231 | 85.6 kb | Distal (>10kb) Multiome | 80 | |
| chr9:38,214,046–38,215,198 | 145.5 kb | Distal (>10kb) Multiome | 249 | |
| chr9:38,226,445–38,227,547 | 157.8 kb | Distal (>10kb) Multiome | 478 |
Genomic view of the SHB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.