SHARPIN

SHANK associated RH domain interactor | DKFZP434N1923, SIPL1

Enables polyubiquitin modification-dependent protein binding activity. Involved in defense response to bacterium; protein linear polyubiquitination; and regulation of signal transduction. Located in cytosol. Part of LUBAC complex. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 25 terms

LUBAC complex (GO:0071797)LUBAC complex (GO:0071797)LUBAC complex (GO:0071797)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)defense response to bacterium (GO:0042742)negative regulation of inflammatory response (GO:0050728)negative regulation of inflammatory response (GO:0050728)polyubiquitin modification-dependent protein binding (GO:0031593)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein binding (GO:0005515)protein linear polyubiquitination (GO:0097039)protein linear polyubiquitination (GO:0097039)protein ubiquitination (GO:0016567)protein-macromolecule adaptor activity (GO:0030674)regulation of CD40 signaling pathway (GO:2000348)regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)synapse (GO:0045202)ubiquitin binding (GO:0043130)ubiquitin-protein transferase activity (GO:0004842)

Expression (TPM)

TFs regulating SHARPIN 0 TFs

Transcription factors with Perturb-seq knockdown data for SHARPIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SHARPIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SHARPIN

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SHARPIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:143,814,945–143,816,493	288.5 kb	Distal (>10kb) Multiome	893
chr8:143,828,724–143,829,946	274.9 kb	Distal (>10kb) Multiome	933
chr8:143,840,284–143,841,979	263.1 kb	Distal (>10kb) Multiome	551
chr8:143,877,814–143,879,346	225.7 kb	Distal (>10kb) Multiome	444
chr8:143,941,814–143,942,929	162.0 kb	Distal (>10kb) Multiome	630
chr8:143,943,562–143,944,432	160.2 kb	Distal (>10kb) Multiome	587
chr8:143,951,583–143,954,394	150.4 kb	Distal (>10kb) Multiome	943
chr8:143,972,817–143,973,908	130.7 kb	Distal (>10kb) Multiome	436
chr8:143,976,288–143,977,568	127.2 kb	Distal (>10kb) Multiome	738
chr8:143,989,521–143,991,038	114.2 kb	Distal (>10kb) Multiome	596
chr8:144,049,063–144,051,761	53.6 kb	Distal (>10kb) Multiome	342
chr8:144,060,259–144,061,087	43.5 kb	Distal (>10kb) Multiome	727
chr8:144,078,142–144,079,235	25.6 kb	Distal (>10kb) Multiome	912
chr8:144,082,187–144,083,105	21.7 kb	Distal (>10kb) Multiome	763
chr8:144,094,454–144,095,491	9.3 kb	Proximal (<10kb) Multiome	798
chr8:144,095,921–144,096,310	7.5 kb	Proximal (<10kb)	466
chr8:144,103,485–144,105,242	65 bp	At TSS Multiome	1033
chr8:144,108,038–144,108,663	4.1 kb	Proximal (<10kb) Multiome	137
chr8:144,137,565–144,138,500	33.5 kb	Distal (>10kb) Multiome	817
chr8:144,146,820–144,149,073	43.7 kb	Distal (>10kb) Multiome	790
chr8:144,266,293–144,267,098	162.2 kb	Distal (>10kb) Multiome	162
chr8:144,290,981–144,292,410	187.2 kb	Distal (>10kb) Multiome	716
chr8:144,315,833–144,316,450	211.9 kb	Distal (>10kb) Multiome	396
chr8:144,325,768–144,327,719	222.6 kb	Distal (>10kb) Multiome	1016
chr8:144,331,281–144,333,847	227.7 kb	Distal (>10kb) Multiome	406
chr8:144,336,102–144,339,119	232.6 kb	Distal (>10kb) Multiome	922
chr8:144,353,907–144,355,227	250.3 kb	Distal (>10kb) Multiome	280
chr8:144,358,142–144,359,070	254.3 kb	Distal (>10kb) Multiome	719
chr8:144,369,349–144,369,916	265.4 kb	Distal (>10kb) Multiome	204
chr8:144,372,497–144,372,883	268.4 kb	Distal (>10kb) Multiome	160
chr8:144,372,993–144,375,084	269.7 kb	Distal (>10kb) Multiome	903

Genome Browser

Genomic view of the SHARPIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.