Enables protein phosphatase 1 binding activity and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of JNK cascade; protein autoubiquitination; and regulation of protein metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SH3RF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3RF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3RF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:144,170,148–144,171,312 | 1765.8 kb | Distal (>10kb) Multiome HiCAR | 729 | |
| chr5:145,834,746–145,836,489 | 101.1 kb | Distal (>10kb) Multiome | 918 | |
| chr5:145,855,918–145,856,897 | 80.1 kb | Distal (>10kb) Multiome | 434 | |
| chr5:145,936,249–145,937,190 | 73 bp | At TSS Multiome | 653 | |
| chr5:145,937,384–145,938,457 | 807 bp | At TSS | 323 | |
| chr5:145,945,659–145,946,222 | 9.1 kb | Proximal (<10kb) | 99 | |
| chr5:146,026,278–146,026,799 | 89.9 kb | Distal (>10kb) Multiome | 138 | |
| chr5:146,073,032–146,074,223 | 137.1 kb | Distal (>10kb) Multiome | 179 | |
| chr5:146,182,165–146,183,510 | 246.2 kb | Distal (>10kb) Multiome | 994 | |
| chr5:146,202,953–146,204,079 | 266.9 kb | Distal (>10kb) Multiome | 825 |
Genomic view of the SH3RF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.