Enables guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Acts upstream of or within intracellular signal transduction. Located in cytoplasmic vesicle membrane and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SH3BP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3BP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3BP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:15,064,860–15,065,480 | 267.3 kb | Distal (>10kb) Multiome | 832 | |
| chr3:15,098,771–15,099,764 | 233.4 kb | Distal (>10kb) Multiome | 1059 | |
| chr3:15,118,530–15,119,129 | 213.7 kb | Distal (>10kb) Multiome | 281 | |
| chr3:15,305,253–15,306,068 | 26.9 kb | Distal (>10kb) Multiome | 367 | |
| chr3:15,331,772–15,333,155 | 89 bp | At TSS Multiome | 642 | |
| chr3:15,356,271–15,357,033 | 24.1 kb | Distal (>10kb) Multiome | 98 | |
| chr3:15,377,980–15,378,549 | 45.8 kb | Distal (>10kb) Multiome | 575 | |
| chr3:15,427,190–15,427,854 | 94.9 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the SH3BP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.