This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for SH3BP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3BP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3BP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,419,824–37,420,580 | 219.4 kb | Distal (>10kb) Multiome | 150 | |
| chr22:37,518,831–37,519,884 | 120.2 kb | Distal (>10kb) Multiome | 548 | |
| chr22:37,545,569–37,546,885 | 93.3 kb | Distal (>10kb) Multiome | 682 | |
| chr22:37,559,893–37,560,965 | 79.3 kb | Distal (>10kb) Multiome | 589 | |
| chr22:37,569,013–37,570,549 | 70.2 kb | Distal (>10kb) Multiome | 695 | |
| chr22:37,608,044–37,609,455 | 30.9 kb | Distal (>10kb) Multiome | 920 | |
| chr22:37,639,157–37,639,951 | 102 bp | At TSS Multiome | 427 | |
| chr22:37,640,160–37,640,360 | 492 bp | At TSS | 170 | |
| chr22:37,643,338–37,643,564 | 3.7 kb | Proximal (<10kb) | 249 | |
| chr22:37,658,172–37,659,508 | 18.9 kb | Distal (>10kb) Multiome | 722 | |
| chr22:37,674,916–37,675,641 | 35.8 kb | Distal (>10kb) Multiome | 607 | |
| chr22:37,676,590–37,677,674 | 37.6 kb | Distal (>10kb) Multiome | 655 | |
| chr22:37,686,104–37,686,784 | 46.8 kb | Distal (>10kb) Multiome | 866 | |
| chr22:37,696,496–37,697,685 | 57.2 kb | Distal (>10kb) Multiome | 428 | |
| chr22:37,745,641–37,746,995 | 106.5 kb | Distal (>10kb) Multiome | 627 | |
| chr22:37,802,124–37,802,989 | 162.7 kb | Distal (>10kb) Multiome | 603 | |
| chr22:37,804,679–37,805,768 | 165.6 kb | Distal (>10kb) Multiome | 763 | |
| chr22:37,807,436–37,808,267 | 168.2 kb | Distal (>10kb) Multiome | 766 | |
| chr22:37,817,672–37,819,114 | 178.2 kb | Distal (>10kb) Multiome | 713 | |
| chr22:37,824,524–37,825,593 | 185.3 kb | Distal (>10kb) Multiome | 173 | |
| chr22:37,843,748–37,844,743 | 204.7 kb | Distal (>10kb) Multiome | 798 | |
| chr22:37,849,215–37,849,709 | 209.7 kb | Distal (>10kb) Multiome | 753 | |
| chr22:37,905,849–37,906,846 | 266.6 kb | Distal (>10kb) Multiome | 552 | |
| chr22:37,933,777–37,934,256 | 294.4 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the SH3BP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.