Predicted to enable SH3 domain binding activity. Located in nuclear membrane and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SH3BGRL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH3BGRL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH3BGRL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:79,536,670–79,538,229 | 93.9 kb | Distal (>10kb) Multiome | 794 | |
| chr6:79,568,949–79,569,872 | 62.0 kb | Distal (>10kb) Multiome | 38 | |
| chr6:79,570,263–79,571,258 | 60.6 kb | Distal (>10kb) Multiome | 384 | |
| chr6:79,630,790–79,632,025 | 41 bp | At TSS Multiome | 750 | |
| chr6:79,777,822–79,779,056 | 146.9 kb | Distal (>10kb) Multiome | 471 | |
| chr6:79,869,214–79,870,099 | 238.5 kb | Distal (>10kb) Multiome | 584 |
Genomic view of the SH3BGRL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.