This gene encodes a member of the SH2-domain containing mediators family. The encoded protein mediates activation of various kinases and may function in cytokine and growth factor receptor signaling and cellular transformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for SH2B1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SH2B1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SH2B1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:28,553,780–28,554,756 | 292.5 kb | Distal (>10kb) Multiome | 995 | |
| chr16:28,822,471–28,824,789 | 22.5 kb | Distal (>10kb) Multiome | 1145 | |
| chr16:28,845,867–28,847,117 | 134 bp | At TSS Multiome | 995 | |
| chr16:28,863,149–28,864,223 | 16.9 kb | Distal (>10kb) Multiome | 996 | |
| chr16:28,879,620–28,880,509 | 33.3 kb | Distal (>10kb) Multiome | 559 | |
| chr16:28,923,986–28,926,025 | 78.3 kb | Distal (>10kb) Multiome | 1053 | |
| chr16:28,936,364–28,936,885 | 90.0 kb | Distal (>10kb) Multiome | 419 | |
| chr16:28,945,417–28,946,070 | 99.1 kb | Distal (>10kb) Multiome | 916 | |
| chr16:28,950,343–28,951,586 | 104.2 kb | Distal (>10kb) Multiome | 797 | |
| chr16:28,974,026–28,975,195 | 128.0 kb | Distal (>10kb) Multiome | 996 |
Genomic view of the SH2B1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.