The protein encoded by this gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for SGSM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGSM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGSM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:2,041,423–2,042,366 | 295.6 kb | Distal (>10kb) Multiome | 834 | |
| chr17:2,048,764–2,051,218 | 288.4 kb | Distal (>10kb) Multiome | 658 | |
| chr17:2,053,643–2,054,179 | 283.7 kb | Distal (>10kb) Multiome | 473 | |
| chr17:2,054,616–2,055,766 | 282.4 kb | Distal (>10kb) Multiome | 544 | |
| chr17:2,058,401–2,059,503 | 278.7 kb | Distal (>10kb) Multiome | 366 | |
| chr17:2,302,778–2,304,288 | 33.8 kb | Distal (>10kb) Multiome | 770 | |
| chr17:2,336,166–2,337,712 | 1.0 kb | Proximal (<10kb) Multiome | 896 | |
| chr17:2,337,831–2,338,296 | 334 bp | At TSS | 392 | |
| chr17:2,392,290–2,394,855 | 55.4 kb | Distal (>10kb) Multiome | 788 | |
| chr17:2,396,361–2,397,494 | 59.5 kb | Distal (>10kb) Multiome | 546 | |
| chr17:2,398,260–2,402,837 | 62.2 kb | Distal (>10kb) Multiome | 1128 | |
| chr17:2,511,517–2,512,317 | 174.4 kb | Distal (>10kb) Multiome | 698 | |
| chr17:2,592,971–2,594,792 | 256.1 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the SGSM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.