Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
Transcription factors with Perturb-seq knockdown data for SGPP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGPP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGPP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:63,542,200–63,544,165 | 184.6 kb | Distal (>10kb) Multiome | 829 | |
| chr14:63,641,240–63,642,923 | 86.1 kb | Distal (>10kb) Multiome | 1029 | |
| chr14:63,727,188–63,728,615 | at TSS | At TSS Multiome | 737 | |
| chr14:63,730,810–63,731,054 | 2.7 kb | Proximal (<10kb) | 27 | |
| chr14:63,852,350–63,854,165 | 124.9 kb | Distal (>10kb) Multiome | 591 | |
| chr14:63,891,140–63,891,876 | 163.4 kb | Distal (>10kb) Multiome | 157 |
Genomic view of the SGPP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.