This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for SGK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:133,888,652–133,890,259 | 285.8 kb | Distal (>10kb) Multiome | 323 | |
| chr6:133,891,167–133,891,948 | 283.3 kb | Distal (>10kb) Multiome | 305 | |
| chr6:133,916,620–133,917,311 | 258.0 kb | Distal (>10kb) Multiome | 344 | |
| chr6:133,951,916–133,953,876 | 221.7 kb | Distal (>10kb) Multiome | 1096 | |
| chr6:134,052,117–134,053,097 | 122.3 kb | Distal (>10kb) Multiome | 520 | |
| chr6:134,074,125–134,074,941 | 100.3 kb | Distal (>10kb) Multiome | 190 | |
| chr6:134,173,985–134,177,008 | 146 bp | At TSS Multiome | 1094 | |
| chr6:134,178,107–134,178,954 | 3.7 kb | Proximal (<10kb) Multiome | 484 | |
| chr6:134,182,634–134,182,855 | 7.8 kb | Proximal (<10kb) | 137 | |
| chr6:134,379,008–134,379,485 | 204.4 kb | Distal (>10kb) Multiome HiCAR | 161 |
Genomic view of the SGK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.