CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]
Transcription factors with Perturb-seq knockdown data for SGF29. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SGF29 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SGF29, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:28,267,361–28,267,924 | 286.4 kb | Distal (>10kb) Multiome | 36 | |
| chr16:28,277,564–28,278,417 | 276.0 kb | Distal (>10kb) Multiome | 598 | |
| chr16:28,291,632–28,293,697 | 260.4 kb | Distal (>10kb) Multiome HiCAR | 578 | |
| chr16:28,491,428–28,492,451 | 61.9 kb | Distal (>10kb) Multiome | 879 | |
| chr16:28,553,780–28,554,756 | 194 bp | At TSS Multiome | 995 | |
| chr16:28,822,471–28,824,789 | 270.1 kb | Distal (>10kb) Multiome | 1145 | |
| chr16:28,845,867–28,847,117 | 292.5 kb | Distal (>10kb) Multiome | 995 |
Genomic view of the SGF29 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.