Predicted to be involved in protein transport and vesicle-mediated transport. Predicted to be located in several cellular components, including cytoplasm; endomembrane system; and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for SFT2D1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SFT2D1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SFT2D1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:166,097,427–166,098,419 | 244.6 kb | Distal (>10kb) Multiome | 280 | |
| chr6:166,166,366–166,169,959 | 174.5 kb | Distal (>10kb) Multiome | 361 | |
| chr6:166,194,896–166,195,965 | 147.1 kb | Distal (>10kb) Multiome | 171 | |
| chr6:166,204,810–166,205,524 | 137.5 kb | Distal (>10kb) Multiome | 164 | |
| chr6:166,252,782–166,254,328 | 89.1 kb | Distal (>10kb) Multiome | 340 | |
| chr6:166,307,009–166,308,841 | 35.1 kb | Distal (>10kb) Multiome | 511 | |
| chr6:166,325,438–166,325,914 | 16.9 kb | Distal (>10kb) Multiome | 117 | |
| chr6:166,342,181–166,343,145 | 88 bp | At TSS Multiome | 976 | |
| chr6:166,352,052–166,352,264 | 9.5 kb | Proximal (<10kb) | 225 | |
| chr6:166,381,861–166,384,011 | 40.6 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:166,392,771–166,393,974 | 50.8 kb | Distal (>10kb) Multiome | 201 | |
| chr6:166,551,739–166,552,446 | 209.6 kb | Distal (>10kb) Multiome | 88 | |
| chr6:166,626,261–166,628,806 | 284.9 kb | Distal (>10kb) Multiome | 711 |
Genomic view of the SFT2D1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.